Targeting DNA repair pathways in triple negative breast cancer

Marilyn Santo, West Virginia, USA 16-18

Triple negative breast cancer is an aggressive subtype of breast cancer with all three hormone receptors (estrogen, progesterone, and HER-2) not over-expressed in the cancer tumor. Due to the lack of these targets, traditional treatments such as hormone therapy and chemotherapy are ineffective, which makes this breast cancer one of the hardest to treat. My project focused on targeting DNA repair pathways in triple negative breast cancer with two objectives: compare the extent of damage between two ethnicities and evaluate their response to targeted treatment.

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