Intelligent nanorobotic systems for neurodegenerative disease treatment

Sofiya Lysenko, Pennsylvania, USA 16-18

The purpose of this project is to develop and program a self-folded computationally driven DNA robot that can facilitate a pathway across the blood-brain barrier and sense and respond to its environment, performing computation similar to a silicon-based computer. The design supersedes current drug-delivery methods in many aspects since programmable computation within biological systems such as DNA can lead to high specificity and therapeutics that respond to their environment, which is important for current challenges and progress in reforming chemotherapeutics and the race toward improved accuracy and optimization in neurodegenerative drugs. Additionally, the blood-brain barrier’s acceptance to DNA makes DNA a much more robust and less invasive vehicle option for drug delivery to the brain.

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