BA-ADA–based ROS-responsive nanoparticles for selective drug delivery in cancer cells

I Sam Hui, Sap Tou Lao, Chris Fong, Macau 13-15

A study was conducted on ROS-responsive nanoparticles. An innovative synthetic molecule from 4-Hydroxyphenylboronic acid pinacol ester conjugated 1-Adamantanecarboxylic acid (BA-ADA) was designed for our study. A therapeutic payload (doxorubicin) can be loaded into the nanoparticles and selectively released within cancer tissues where ROS is overexpressed. This can enhance therapeutic efficacy and reduce side effects in comparison to most mainstream medical approaches. The research and innovative purposes are to establish a more humane and effective intervention strategy so that cancer cells can be targeted specifically and effectively.

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