A New Anti-Flu MedicineEric Chen, USA Grand Prize, Age Category Award, 17-18
The emergence of new highly lethal influenza viruses such as H5N1 and H7N9 poses a grave threat to the world. My project is to discover novel influenza endonuclease inhibitors as leads for a new type of anti-flu medicine, effective against all influenza viruses including pandemic strains. By combining computer modeling and biological studies, I identified a number of novel, potent endonuclease inhibitors. I also performed comprehensive structural analysis, laying ground work for further design and optimization of the anti-flu drug candidates.