A novel genomic approach for acute rejection across all age groups in kidney transplantation

Daniel Cheng, North Carolina, USA 16-18

Acute rejection remains a significant complication in kidney transplantation, which affects long-term outcomes. Working with summer high school student volunteers at Duke University, we developed a peripheral blood gene expression signature of acute rejection that could be used in both pediatric and adult recipients. This peripheral signature of acute rejection will allow for improved monitoring of allografts in pediatric patients as they progress to adulthood, allowing for immunosuppression titration and improvement in long-term outcomes. This research has been accepted to present at the June 2019 American Transplant Congress in Boston, MA.

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