Finding a cure for Long QT syndrome: would atenolol work?

Charles Chiang, Indiana, USA 16-18

I used the publicly available animal data from the Health and Environmental Sciences Institute to investigate the effect of atenolol on the QT interval. Currently there is no effective treatment for patients with Long QT syndrome, and beta blockers such as atenolol have been used off-label for these patients. It is important to evaluate whether treatments using atenolol can provide benefits in dogs before they are further investigated in humans. In electrocardiograms, QT interval is correlated physiologically with heart rate. Hence, extensive statistical analyses were performed to “correct”’ treatment-induced changes in QT interval independent of changes in heart rate.

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